Description
Tilmicosin is a broad –spectrum semi-synthetic bactericidal macrolide antibiotic synthesized from tylosin. it has an antibacterial spectrum that is predominantly effective against mycoplasma,pasteurella and heamopilus spp. and various gram-positive organisms such as corynebacterium spp. it is believed to affect bacterial protein synthesis through binding to 50s ribosomal subunits. cross-resistance between tilmicosin and macrolide antibiotics has been observed. following oral administration, tilmicosin is excreted mainly via the bile into the faeces, with a small proportion being excreted via the urine.
Indications
For the treatment of respiratory infections associated with tilmicosin-susceptible micro-organisms such as mycoplasma spp. pasteurella multocida, actinobacillus pleuropneumoniae, actinomyces pyogenes and mannheimia haemolytica in calves, chickens, turkeys and swine.
Dosage and administration
For oral administration:
Calves: twice daily, 1ml per20 kgbody weight via (artificia) milk for 3-5days.
Poultry: 300ml per 1000 litres of drinking water (75ppm) for 3 days.
Swine: 800ml per 1000litres of drinking water (200ppm) for 5 days.
Note: medicated drinking water or (artificial) milk should be prepared fresh every 24h. to ensure a correct dosage, the concentration of the product should be adjusted to the actual fluid intake.
Contraindications
Hypersensitivity or resistance to tilmicosin.
Concurrent administration of other macrolides or lincosamides.
Administration to animals with an active microbial digestion or to equine or caprine species.
Administration to poultry producing eggs human consumption or to animals intended for breeding purposes.
During pregnancy and lactation, use only after a risk/benefit assessment by a veterinarian.
Precautions
1. Used for animals with gastrointestinal ulcers, kidney disease, liver disease or a history of blood with caution.
2. With caution for the treatment of acute abdomen, can cover up the behavior caused by endotoxemia and intestinal lose vitality and cardiopulmonary signs.
3. With caution used in pregnant animals.
4. an artery injection, otherwise it will cause central nerve stimulation, ataxia, hyperventilation and muscle weakness.
5. Horse will appear potential gastrointestinal intolerance, hypoalbuminemia, congenital diseases. Dogs can appear lower gastrointestinal function.
Withdrawal period
For meat: calves: 42days.
Broilers: 12days.
Turkeys: 19days.
Swine: 14days
Storage
Storage: store in the room temperature and protecting from light.
Keep out of the touch of children and for veterinary use only.
